Journal
BIOANALYSIS
Volume 10, Issue 4, Pages 257-271Publisher
FUTURE SCI LTD
DOI: 10.4155/bio-2017-0153
Keywords
ambient ionization; biocompatible; direct analysis; high-throughput analysis; MS; SPME; spot analysis
Funding
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Thermo Fisher Scientific
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Coated blade spray (CBS) is a solid-phase microextraction-based technology that can be directly coupled to MS to enable the rapid qualitative and quantitative analysis of complex matrices. The goal of this mini review is to concisely introduce CBS's operational fundamentals and to consider how it correlates/contrasts with existing direct-to-MS technologies suitable for bioanalytical applications. In addition, we provide a fair comparison of CBS to other existing solid-phase microextraction-to-MS approaches, as well as an overview of recent CBS applications/strategies that have been developed to analyze diverse compounds present in biofluids.
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