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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
Masaaki Komatsu et al.
CELL (2007)
Autophagy, amyloidogenesis and Alzheimer disease
Ralph A. Nixon
JOURNAL OF CELL SCIENCE (2007)
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
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JOURNAL OF CELL BIOLOGY (2007)
Aging and regulated protein degradation: who has the UPPer hand?
Vita A. Vernace et al.
AGING CELL (2007)
SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release
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CELL (2007)
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion
Hitoshi Nakatogawa et al.
CELL (2007)
The functions of UCH-L1 and its relation to neurodegenerative diseases
Rieko Setsuie et al.
NEUROCHEMISTRY INTERNATIONAL (2007)
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
Udai Bhan Pandey et al.
NATURE (2007)
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein
Sovan Sarkar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Amyloid, hypometabolism, and cognition in Alzheimer disease - An [11C]PIB and [18F]FDG PET study
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NEUROLOGY (2007)
Proteasome inhibition triggers activity-dependent increase in the size of the recycling vesicle pool in cultured hippocampal neurons
Kristen Willeumier et al.
JOURNAL OF NEUROSCIENCE (2006)
A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP
Rosalina Fonseca et al.
NEURON (2006)
Ubiquitin hydrolase Uch-L1 rescues β-amyloid-induced decreases in synaptic function and contextual memory
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CELL (2006)
Activity-dependent dynamics and sequestration of proteasomes in dendritic spines
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NATURE (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation
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MOLECULAR CELL (2006)
β-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system
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JOURNAL OF NEUROSCIENCE (2006)
Synapse formation and plasticity: recent insights from the perspective of the ubiquitin proteasome system
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CURRENT OPINION IN NEUROBIOLOGY (2006)
Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains
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NEUROBIOLOGY OF AGING (2006)
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
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JOURNAL OF CELL BIOLOGY (2005)
Overexpression of proteasome β5 subunit increases the amount of assembled proteasome and confers ameliorated response to oxidative stress and higher survival rates
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
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JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
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MOLECULAR AND CELLULAR BIOLOGY (2004)
Reactivation of HSV-1 in the brain of patients with familial Alzheimer's disease
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JOURNAL OF MEDICAL VIROLOGY (2004)
Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26 S proteasome in fission yeast
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JOURNAL OF MOLECULAR BIOLOGY (2004)
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
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JOURNAL OF CELL SCIENCE (2004)
A proteasome-sensitive connection between PSD-95 and GluR1 endocytosis
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NEUROPHARMACOLOGY (2004)
BACE1 - The beta-secretase enzyme in Alzheimer's disease
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JOURNAL OF MOLECULAR NEUROSCIENCE (2004)
Protein degradation and protection against misfolded or damaged proteins
AL Goldberg
NATURE (2003)
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
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CELL (2003)
The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg
A Ciechanover et al.
NEURON (2003)
α-synuclein is degraded by both autophagy and the proteasome
JL Webb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Relationship between β-amyloid degradation and the 26S proteasome in neural cells
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EXPERIMENTAL NEUROLOGY (2003)
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
MD Ehlers
NATURE NEUROSCIENCE (2003)
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome
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SCIENCE (2002)
A cryptic protease couples deubiquitination and degradation by the proteasome
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NATURE (2002)
Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The ubiquitin-proteasome cascade is required for mammalian long-term memory formation
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EUROPEAN JOURNAL OF NEUROSCIENCE (2001)
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
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EMBO JOURNAL (2001)
A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems
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TRENDS IN BIOCHEMICAL SCIENCES (2001)
Assembly of the 26S proteasome is regulated by phosphorylation of the p45/Rpt6 ATPase subunit
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BIOCHEMISTRY (2001)
Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer's disease and Down syndrome -: Differential effects of APOE genotype and presenilin mutations
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AMERICAN JOURNAL OF PATHOLOGY (2000)
Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain
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GENE (2000)