Journal
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
Volume 2018, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2018/5893514
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Funding
- Fondation du CHU de Quebec from Universite Laval
- Kidney Foundation of Canada [KFOC160013]
- KRESCENT program from Canadian Institutes of Health Research (CIHR)/Canadian Society of Nephrology (CSN)/Kidney Foundation of Canada (KFOC)/Fonds de Recherche du Quebec Sante (FRQS) [KRES150006]
- Canadian Institutes of Health Research (CIHR)
- Fonds de Recherche du Quebec Sante (FRQS)
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Vascular calcification and bone fragility are common and interrelated health problems that affect chronic kidney disease (CKD) patients. Bone fragility, which leads to higher risk of fracture and mortality, arises from the abnormal bone remodeling and mineralization that are seen in chronic kidney disease. Recently, sclerostin and Dickkopf-related protein 1 were suggested to play a significant role in CKD-related bone disease as they are known inhibitors of the Wnt pathway, thus preventing bone formation. This review focuses on new knowledge about the Wnt pathway in bone, how its function is affected by chronic kidney disease and how this affects bone structure. Expression of components and inhibitors of the Wnt pathway has been shown to be affected by the loss of kidney function, and a better understanding of the bone effects of Wnt pathway inhibitors could allow the development of new therapies to prevent bone fragility in this population.
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