Journal
BMC NEPHROLOGY
Volume 19, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s12882-018-0837-1
Keywords
Chronic kidney disease; Adiposity indices; Percentage body fat; Chinese adults; Cross-sectional study
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Funding
- ministry of Science & Technology, China [2011BAI11B01]
- National Health and Family Planning Commission, China [201402002]
- BUCHANG PHARMA, Xian, China
- Essen Technology Company Limited
- Pfizer China
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Background: The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat index (VFI), percentage body fat (PBF), body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR). Methods: A total of 29,516 participants aged 35 years or above were selected using a stratified multistage random sampling method across China during 2012-2015. CKD was defined as an estimated glomerular filtration (eGFR) < 60 ml/min/1.72m(2). Results: The overall weighted prevalence of CKD was 3.94% (3.62% in males and 4.25% in females). All five adiposity indices had significant negative correlations to eGFR (P < 0.05). The area under the ROC (receiver operating characteristic) curves (AUC) for PBF was almost significantly larger than the other adiposity indices (P < 0. 001). In addition, PBF yielded the highest Youden index in identifying CKD (male: 0.15; female: 0.20). In the logistic analysis, PBF had the highest crude odds ratios (ORs) in both males (OR: 1.819, 95% CI 1.559-2.123) and females (OR: 2.268, 95% CI 1.980-2.597). After adjusted for age, smoking status, alcohol use, education level, marital status, rural vs. urban area, geographic regions, and diagnosis of hypertension, diabetes mellitus, myocardial infarction and stroke, the ORs on PBF remained significant for both genders (P < 0.05). Conclusions: Obesity is associated with an increased risk of CKD. Furthermore, PBF was a better predictor for identifying CKD than other adiposity indices (BMI, WC, WHtR, and VFI).
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