Journal
CHEMICAL SCIENCE
Volume 9, Issue 26, Pages 5781-5786Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sc01669k
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Funding
- Canada Research Chair Foundation
- Canada Foundation for Innovation
- FQRNT Center in Green Chemistry and Catalysis
- Natural Sciences and Engineering Research Council of Canada
- McGill University
- Shanghai Institute of Organic Chemistry (SIOC)
- National Postdoctoral Program for Innovative Talents fellowship [BX201700110]
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Direct introduction of a difluoromethylthio group (-SCF2H) to arenes represents an efficient route to access a valuable catalogue of organofluorines; however, to realize this transformation under metal-free and mild conditions still remains challenging and rarely reported. Herein, a metal-catalyst-free and redox-neutral innate difluoromethylthiolation method with a shelf-stable and readily available reagent, PhSO2SCF2H, under visible light irradiation is described. This light-mediated protocol successfully converts a broad spectrum of arenes and heteroarenes to difluoromethylthioethers in the absence of noble metals and stoichiometric amounts of additives.
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