Journal
NATURE REVIEWS CANCER
Volume 12, Issue 9, Pages 627-637Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3339
Keywords
-
Categories
Funding
- Veterans Administration Career Development Award, NIH [R01 NCI CA131272]
Ask authors/readers for more resources
NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen species-generating enzymes that broadly and specifically regulate redox-sensitive signalling pathways that are involved in cancer development and progression. They act at specific cellular membranes and microdomains through the activation of oncogenes and the inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived ROS, and the biological role of NOX oxidases in the aetiology of cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available