Journal
VIRUSES-BASEL
Volume 10, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/v10010037
Keywords
papillomaviruses; oncoproteins; structure; X-ray; NMR; virus-host interactomics
Categories
Funding
- Ligue contre le Cancer (equipe labellisee)
- National Institutes of Health [R01CA134737]
- Instruct (ESFRI)
- French Infrastructure for Integrated Structural Biology (FRISBI)
- Fondation pour La Recherche Medicale
- NATIONAL CANCER INSTITUTE [R01CA134737] Funding Source: NIH RePORTER
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Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7 have been recalcitrant to high-resolution structure analysis. However, in the last decade a wealth of three-dimensional information has been gained on both proteins whether free or complexed to host target proteins. Here, we first summarize the diverse activities of these small multifunctional oncoproteins. Next, we review the available structural data and the new insights they provide about the evolution of E6 and E7, their multiple interactions and their functional variability across human papillomavirus (HPV) species.
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