Journal
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
Volume 73, Issue 1-2, Pages 49-57Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/znc-2017-0140
Keywords
biological activity; N-acetylborrelidin B; Streptomyces mutabilis sp MII; taxonomy
Funding
- BMBF [031A533]
- German Academic Exchange Service (DAAD)
- German Federal Foreign Office in the frame of the Research Training Network Novel Cytotoxic Drugs from Extremophilic Actinomycetes [ID57166072]
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In the course of our screening program for new bioactive compounds, a naturally new 18-membered macrolide antibiotic, N-acetylborrelidin B (1) along with borrelidin (2) were obtained from the marine Streptomyces mutabilis sp. MII. The strain was isolated from a sediment sample collected in the Red Sea at the Hurghada Coast and characterized taxonomically. Additional nine diverse bioactive compounds were reported: 6-prenyl-indole-3-acetonitrile (3), sitosteryl-3 ss-d-glucoside, campesterol, ferulic acid, linoleic acid methyl ester, linoleic acid, N-acetylanthranilic acid, indole 3-acetic acid methyl ester, indole 3-carboxylic acid, and adenosine. Structure 1 was confirmed by in-depth NMR studies and by mass spectra, and comparison with related literature data. The antimicrobial activity of the strain extract and compounds 1 and 2 were studied using a panel of pathogenic microorganisms. The in vitro cytotoxicity of compounds 1 and 2 as well as the crude extract were tested against the human cervix carcinoma cell line (KB-3-1).
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