Journal
JOURNAL OF IMMUNOLOGY
Volume 189, Issue 5, Pages 1230-1234Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.1126/science.2161559
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Complementary DNA clones encoding mouse cytokines synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis T(H)l helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.
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