Journal
WATER AIR AND SOIL POLLUTION
Volume 229, Issue 3, Pages -Publisher
SPRINGER
DOI: 10.1007/s11270-018-3739-8
Keywords
Developmental toxicity; Oxidative stress; Diethylnitrosamine; Teratogenicity; Zebrafish
Funding
- Scientific Research Project of Medical Service of National Clinical Research Base of Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine [JDZX2015173]
- National Natural Science Foundation of China [21675177]
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Diethylnitrosamine (DEN) is present in food, water, and daily supplies and is regarded as a toxicant of carcinogenicity. The developmental toxicity of DEN has been rarely reported as yet. In this study, zebrafish were exposed to different concentrations of DEN at 6 h postfertilization (hpf) to access embryonic toxicity of the compound. The results show that DEN resulted in negative effects of hatching rate, heartbeat, body length, and spontaneous movement. Deformities, including notochord malformation, pericardium edema, embryonic membrane turbidity, tail hypoplasia, yolk sac deformity, and growth retardation, happened during exposure period. Moreover, production of reactive oxygen species (ROS) significantly increased after DEN treatment. Then, alterations of the expression level of oxidative stress-related genes were observed in our results. To our knowledge, this is the first study concerning the effect of DEN on zebrafish. And from the information of our research, we speculated that development toxicity of DEN should be related to the excessive oxidative stress.
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