Journal
VIROLOGY
Volume 518, Issue -, Pages 423-433Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2018.03.010
Keywords
NCLDV; Mimiviridae; Giant virus; Algal virus; Green algae; Pyruvate formate-Iyase; Auxiliary metabolic genes
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Funding
- National Science Foundation [EF 04-24599, OCE 09-26766, PLR 09-44851, DBI 10-40548, OCE 15-59356]
- Denise B. Evans Fellowship in Oceanographic Research
- Hawai'i Institute of Geophysics and Planetology at the University of Hawai'i at Manoa
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The family Mimiviridae contains uncommonly large viruses, many of which were isolated using a free-living amoeba as a host. Although the genomes of these and other mimivirids that infect marine heterokont and haptophyte protists have now been sequenced, there has yet to be a genomic investigation of a mimivirid that infects a member of the Viridiplantae lineage (green algae and land plants). Here we characterize the 668-kilobase complete genome of TetV-1, a mimivirid that infects the cosmopolitan green alga Tetraselmis (Chlorodendrophyceae). The analysis revealed genes not previously seen in viruses, such as the mannitol metabolism enzyme mannitol 1-phosphate dehydrogenase, the saccharide degradation enzyme alpha-galactosidase, and the key fermentation genes pyruvate formate-lyase and pyruvate formate-lyase activating enzyme. The TetV genome is the largest sequenced to date for a virus that infects a photosynthetic organism, and its genes reveal unprecedented mechanisms by which viruses manipulate their host's metabolism.
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