Journal
VIROLOGY
Volume 518, Issue -, Pages 1-7Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2018.01.028
Keywords
Seneca Valley Virus; Innate immunity; 3C-like protease; IRF3; IRF7
Categories
Funding
- National Natural Sciences Foundation of China [U1501213, 31602035]
- National Key Research and Development Program of China [2016YFD0500901]
- National Science and Technology Ministry [2015BAD12B04]
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Seneca Valley Virus (SVV) is a newly emerged virus belonging to the family Picornaviridae. Basic knowledge of the immunological response to SVV is limited. To date, one study has demonstrated that SW 3C(pro) mediates the cleavage of host MAVS, TRIF, and TANK at specific sites and consequently escapes the host's antiviral innate immunity. In this study, we show that SVV 3C(pro) reduces IRF3 and IRF7 protein expression level and phosphorylation. SVV infection also reduces expression of IRF3 and IRF7 protein. The degradation of IRF3 and IRF7 is dependent on the 3C(pro) protease activity. We also identify interactions between 3C(pro) and IRF3 and IRF7 in PK-15 cells. A detailed analysis revealed that the degradation of IRF3 and IRF7 blocks the transcription of IFN-beta, IFN-alpha 1, IFN-alpha 4, and ISG54. Together, our results demonstrate a novel mechanism developed by SW 3C(pro) to allow the virus to escape the host's intrinsic innate immune system.
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