Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 62, Issue 4, Pages 1132-1140Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2014.2372011
Keywords
Alzheimer's disease (AD); classification; deep Learning; MRI; neuroimaging; positron emission tomography (PET)
Categories
Funding
- ARC
- AADRF
- NA-MIC [NIH U54EB005149]
- NAC [NIH P41EB015902]
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The accurate diagnosis of Alzheimer's disease (AD) is essential for patient care and will be increasingly important as disease modifying agents become available, early in the course of the disease. Although studies have applied machine learning methods for the computer-aided diagnosis of AD, a bottleneck in the diagnostic performance was shown in previous methods, due to the lacking of efficient strategies for representing neuroimaging biomarkers. In this study, we designed a novel diagnostic framework with deep learning architecture to aid the diagnosis of AD. This framework uses a zero-masking strategy for data fusion to extract complementary information from multiple data modalities. Compared to the previous state-of-the-art workflows, our method is capable of fusing multimodal neuroimaging features in one setting and has the potential to require less labeled data. A performance gain was achieved in both binary classification and multiclass classification of AD. The advantages and limitations of the proposed framework are discussed.
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