Journal
LUNG INDIA
Volume 29, Issue 4, Pages 354-362Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0970-2113.102824
Keywords
Cancer; digital clubbing; hypertrophic osteoarthropathy; megakaryocytes; vascular endothelial growth factor
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Digital clubbing is an ancient and important clinical signs in medicine. Although clubbed fingers are mostly asymptomatic, it often predicts the presence of some dreaded underlying diseases. Its exact pathogenesis is not known, but platelet-derived growth factor and vascular endothelial growth factor are recently incriminated in its causation. The association of digital clubbing with various disease processes and its clinical implications are discussed in this review.
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