Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 62, Issue 1, Pages 248-255Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2014.2347284
Keywords
Bioprinting; compressive sensing (CS); fluorescence imaging; image reconstruction; laminar optical tomography (LOT); l(1)-norm regularization; mesoscopic fluorescence molecular tomography (MFMT); molecular imaging; Monte Carlo (MC)
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Funding
- National Science Foundation [CBET-1263455]
- SDPED
- Shandong Province Higher Educational Science and Technology Program [J13LN06]
- Postdoctoral Science Foundation of Shandong Province [201203016]
- National Natural Science Foundation of China [61173173, 61272430]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB019443] Funding Source: NIH RePORTER
- Div Of Chem, Bioeng, Env, & Transp Sys [1263455] Funding Source: National Science Foundation
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Mesoscopic fluorescence molecular tomography (MFMT) is new imaging modality aiming at 3-D imaging of molecular probes in a few millimeter thick biological samples with high-spatial resolution. In this paper, we develop a compressive sensing-based reconstruction method with l1-norm regularization for MFMT with the goal of improving spatial resolution and stability of the optical inverse problem. Three-dimensional numerical simulations of anatomically accurate microvasculature and real data obtained from phantom experiments are employed to evaluate the merits of the proposed method. Experimental results show that the proposed method can achieve 80 mu m spatial resolution for a biological sample of 3 mm thickness and more accurate quantifications of concentrations and locations for the fluorophore distribution than those of the conventional methods.
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