Journal
UROLOGY
Volume 117, Issue -, Pages 9-17Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urology.2018.01.002
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Funding
- National Institutes of Health [RO1 HD059859-05]
- Veterans Affairs Rehabilitation Research and Development Merit Review [I01 RX000228]
- Cleveland Clinic
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Minimally invasive stem cell therapy for stress urinary incontinence may provide an effective nonsurgical treatment for this common condition. Clinical trials of periurethral stem cell injection have been under way, and basic science research has demonstrated the efficacy of both local and systemic stem cell therapies. Results differ as to whether stem cells have a therapeutic effect by differentiating into permanent, functional tissues or exert benefits through a transient presence and the secretion of regenerative factors. This review explores the fate of therapeutic stem cells for stress urinary incontinence and how this may relate to their mechanism of action. Published by Elsevier Inc.
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