Journal
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 42, Issue 9, Pages 1884-1894Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-011-1431-6
Keywords
Autism; Magnetoencephalography; Resting-state; Oscillations; Alpha; Gamma
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Funding
- NICHD NIH HHS [P30 HD026979] Funding Source: Medline
- NIDCD NIH HHS [R01 DC008871, R01DC008871-02S1, R01DC008871] Funding Source: Medline
- NINDS NIH HHS [T32NS007413, T32 NS007413] Funding Source: Medline
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Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and high frequency (20-120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest.
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