Journal
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
Volume 36, Issue 4, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urolonc.2017.11.020
Keywords
Bladder cancer; Tumor-associated macrophages; Lymph node metastasis; Ki-67; CD163; Macrophage traits in tumor cells
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Funding
- FoU research grant from the County Council of Ostergotland, Linkoping, Sweden
- ALF research grant from the County Council of Ostergotland, Linkoping, Sweden
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Background: Tumor-associated macrophages (TAMs) constitute a subset of nonneoplastic cells in tumor stroma and influence cancer progression in solid tumors. The clinical significance of TAMs in urinary bladder cancer (UBC) is controversial. Methods: We prospectively studied 103 patients with stage pT1 T4 UBC treated with cystectomy and pelvic lymph node dissection. Tumor sections were immunostained with M2-specific macrophage marker CD163 and proliferation marker Ki-67. The expression of these markers in cancer cells as well as macrophage infiltration (MI) in tumor stroma was analyzed in relation to clinical data and outcome. Results: The mean rate of CD163 and Ki-67 expressed by cancer cells were 35% and 78%, respectively. With borderline significance, MI was associated with lower rate of lymph node metastasis (P = 0.06). CD163 expression in cancer cells was proportional to MI (P < 0.014). Patients with CD163-positive tumors and strong MI had significantly longer cancer-specific survival (CSS) (76 months), compared to patient with CD163-positive tumors and weak MI (28 months) (P = 0.02). Conclusions: M2-specific MI tends to be inversely correlated with LN metastasis and improved CSS in UBC. MI might have protective impact in CD163-positive tumors. Expression of CD163 in cancer cells is significantly correlated with MI and might have a tumor promoting impact. (C) 2017 Elsevier Inc. All rights reserved.
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