Journal
JOURNAL OF CHEMICAL SCIENCES
Volume 124, Issue 4, Pages 865-869Publisher
INDIAN ACAD SCIENCES
DOI: 10.1007/s12039-012-0284-7
Keywords
Spiro-oxindoles; naphthol; L-proline; isatin
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An efficient synthesis of spiro-oxindoles is accomplished by a one-pot three-component condensation of isatin, malononitrile or cyanoacetic ester and naphthol in the presence of L-proline as a catalyst. This method is of great value because of its shorter reaction times, high yield, and easy processing.
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