Journal
ULTRASONICS SONOCHEMISTRY
Volume 41, Issue -, Pages 213-226Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ultsonch.2017.09.042
Keywords
Agomelatine; Nanoemulsion; Pseudo-ternary phase diagram; Ulffasonication; Central composite design; Atomic force microscopy
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Funding
- University Grants Commission, New Delhi, India [F1-17.1/201647/MANF-2015-17-BIH-61518]
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The objective of present study was to develop a nanoemulsion formulation of agomelatine (BCS class II drug) for the solubility enhancement. Capmul MCM, Tween 80 and PEG-400 were selected as oil, surfactant and co-surfactant respectively. The high energy ultrasonication method was used for the preparation of nanoemulsion. Three-factor three-level central composite design was employed to get the best formulation. The independent variables selected for the optimization were % oil, %S-mix and sonication time (second). Based on the constraints applied to independent and dependent variables, the optimized formulation was selected with 2% oil, 10% Smix and 45 s sonication time. The experimental values for dependent variables such as hydrodynamic diameter (nm), % transmittance and % CDR were found to be 73.72 +/- 2.53 nm, 98.2 +/- 0.42%, 84.71 +/- 4.05% respectively. TEM and AFM - assisted morphological characterization of optimized Ago-NE was done and it was found with a spherical shape. The PDI, Zeta potential and the refractive index of optimized Ago-NE were found to be 0.137 +/- 0.016, -7.40 +/- 0.12 mV and 1.423 +/- 0.045 respectively. The viscosity, pH and drug content of optimized Ago-NE were found as 25.12 +/- 0.67 cP, 6.4 +/- 0.17 and 97.83 +/- 1.03% respectively. The ex-vivo permeation profile of optimized Ago-NE and agomelatine suspension through goat nasal mucosa were compared till 12 h and % cumulative drug permeated was found to be 90% and 40% respectively. The higher drug permeation profile of optimized Ago-NE confirmed that the solubility of agomelatine has been improved.
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