Journal
RADIOCHIMICA ACTA
Volume 100, Issue 8-9, Pages 653-667Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1524/ract.2012.1964
Keywords
Radiometals; Bifunctional chelates; Specific targeting; Nuclear imaging; Radiotherapy
Funding
- NIBIB [5 T32 EB004822]
- US Department of Veterans Affairs
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Radiometals play an important role in diagnostic and therapeutic radiopharmaceuticals. This field of radiochemistry is multidisciplinary, involving radiometal production, separation of the radiometal from its target, chelate design for complexing the radiometal in a biologically stable environment, specific targeting of the radiometal to its in vivo site, and nuclear imaging and/or radiotherapy applications of the resultant radiopharmaceutical. The critical importance of inorganic chemistry in the design and application of radiometal-containing imaging and therapy agents is described from a historical perspective to future directions.
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