Selective Cell-adhesion on Micro-structured Fine Particles

The present paper describes spatially selective adhesion of rat phenochromocytoma (PC 12) cells on micro-structured fine particles. The particles are packed hexagonally in two-dimensional arrangements by self-assembly. Incubation allows most cells to be successfully adhered to the region of self-assembled particles, while few cells are found on the rest of the glass substrate. The line-and-space structure of particles aligns the cells in straight lines. The desired location of cells can be obtained for both appropriate line width and space of particles, because they dominate a spatial selectivity of cell adhesion.