Journal
TRENDS IN NEUROSCIENCES
Volume 41, Issue 2, Pages 72-74Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2017.11.005
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Funding
- National Institutes of Health [MH070727]
- Division of Basic Sciences Training Program National Institutes of Health at UT Southwestern Medical Center [T32 GM008203]
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Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.
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