Journal
TRENDS IN NEUROSCIENCES
Volume 41, Issue 3, Pages 150-160Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2018.01.003
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Funding
- National Institute of General Medical Sciences of the National Institutes of Health, USA [R01GM098578, R01GM111293, R01124248, R01GM056398]
- James S. McDonnell Foundation, USA
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM056398, R01GM124248, R01GM111293, R01GM098578] Funding Source: NIH RePORTER
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The biological basis of consciousness is one of the most challenging and fundamental questions in 21st century science. A related pursuit aims to identify the neural correlates and causes of unconsciousness. We review current trends in the investigation of physiological, pharmacological, and pathological states of unconsciousness at the level of large-scale functional brain networks. We focus on the roles of brain connectivity, repertoire, graphtheoretical techniques, and neural dynamics in understanding the functional brain disconnections and reduced complexity that appear to characterize these states. Persistent questions in the field, such as distinguishing true correlates, linking neural scales, and understanding differential recovery patterns, are also addressed.
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