Journal
TRENDS IN NEUROSCIENCES
Volume 41, Issue 9, Pages 625-639Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2018.06.004
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Funding
- NINDS, NIH [R01 NS081112, R01 NS095366]
- NIH [R01 NS090617]
- Craig H. Neilsen Foundation [338432, 381793]
- Pennsylvania Department of Health CURE program
- Lisa Dean Moseley Foundation
- United States Department of Defense (CDMRP) [SC140038]
- Drexel Deans Fellowship for Collaborative or Themed Research
- Spinal Cord Research Center at Drexel University, College of Medicine (NIH) [P01 NS 055976]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS090617, R01NS081112, R01NS095366, P01NS055976] Funding Source: NIH RePORTER
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The central nervous system is not a static, hard-wired organ. Examples of neuroplasticity, whether at the level of the synapse, the cell, or within and between circuits, can be found during development, throughout the progression of disease, or after injury. One essential component of the molecular, anatomical, and functional changes associated with neuroplasticity is the spinal interneuron (SpIN). Here, we draw on recent multidisciplinary studies to identify and interrogate subsets of SpINs and their roles in locomotor and respiratory circuits. We highlight some of the recent progress that elucidates the importance of SpINs in circuits affected by spinal cord injury (SCI), especially those within respiratory networks; we also discuss potential ways that spinal neuroplasticity can be therapeutically harnessed for recovery.
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