Journal
TRENDS IN NEUROSCIENCES
Volume 41, Issue 1, Pages 18-30Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2017.10.006
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Funding
- Wellcome Trust strategic award [102616, 09846]
- Medical Research Council [P026028/1]
- Oxford Health NIHR Biomedical Research Centre
- MRC [MR/P026028/1] Funding Source: UKRI
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Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly apparent that the bipolar phenotype is more complex and nuanced than simply one of recurring manic and depressive episodes. One such feature is persistent mood instability, and efforts are underway to understand its mechanisms and its therapeutic potential. BD illustrates how psychiatry is being transformed by contemporary neuroscience, genomics, and digital approaches.
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