Journal
TRENDS IN MOLECULAR MEDICINE
Volume 24, Issue 4, Pages 379-394Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2018.02.007
Keywords
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Funding
- French societies ARSEP (Fondation pour l'Aide a la Recherche sur la Sclerose en Plaques)
- AFM (Association Francaise Contre les Myopathies)
- Walter and IIse Rose Foundation
- Peek & Cloppenburg Dusseldorf Foundation
- Agence Nationale de la Recherche [ANR-08-MNPS-041]
- French patient association ARSEP
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The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained elusive. A new category of pathogenic components, normally dormant within human genomes, has been identified: human endogenous retroviruses (HERVs). These represent similar to 8% of the human genome, and environmental factors have reproducibly been shown to trigger their expression. The resulting production of envelope (Env) proteins from HERV-W and HERV-K appears to engage pathophysiological pathways leading to the pathognomonic features of MS and ALS, respectively. Pathogenic HERV elements may thus provide a missing link in understanding these complex diseases. Moreover, their neutralization may represent a promising strategy to establish novel and more powerful therapeutic approaches.
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