Journal
TRENDS IN MICROBIOLOGY
Volume 26, Issue 1, Pages 33-42Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2017.07.006
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Funding
- NATIONAL CANCER INSTITUTE [R01CA177337] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI129540] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK100257] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA177337] Funding Source: Medline
- NIAID NIH HHS [R01 AI129540] Funding Source: Medline
- NIDDK NIH HHS [R01 DK100257] Funding Source: Medline
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Hepatitis B virus (HBV) chronically infects 250 million people worldwide, resulting in nearly one million deaths annually. Studies in recent years have significantly improved our knowledge on the mechanisms of HBV persistence. HBV uses multiple pathways to harness host innate immunity to enhance its replication. It can also take advantage of the developing immune system and the not-yet-stabilized gut microbiota of young children to facilitate its persistence, and use maternal viral e antigen to educate immunity of the offspring to support its persistence after vertical transmission. The knowledge gained from these recent studies paves the way for the development of new therapies for the treatment of chronic HBV infection, which has so far been very challenging.
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