Journal
TRENDS IN MICROBIOLOGY
Volume 26, Issue 4, Pages 284-295Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2018.01.007
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Funding
- Burroughs Wellcome Fund
- UK Biotechnology and Biological Research Council [BB/K017365/1]
- UK Medical Research Council [MR/M026663/1]
- Wellcome Trust [097377]
- MRC Centre for Medical Mycology
- University of Aberdeen [MR/M026663/1]
- BBSRC [BB/K017365/1, BB/R00966X/1] Funding Source: UKRI
- MRC [MR/L00903X/1, MR/M026663/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K017365/1, BB/R00966X/1] Funding Source: researchfish
- Medical Research Council [MR/M026663/1, MR/L00903X/1] Funding Source: researchfish
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Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.
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