Journal
TRENDS IN MICROBIOLOGY
Volume 26, Issue 9, Pages 781-793Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2018.02.007
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Funding
- NIAID NIH HHS [R01 AI127893, T32 AI083203] Funding Source: Medline
- NIGMS NIH HHS [R01 GM102198, R35 GM119774] Funding Source: Medline
- NIH HHS [S10 OD020069] Funding Source: Medline
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The rapid global evolution of influenza virus begins with mutations that arise de novo in individual infections, but little is known about how evolution occurs within hosts. We review recent progress in understanding how and why influenza viruses evolve within human hosts. Advances in deep sequencing make it possible to measure within-host genetic diversity in both acute and chronic influenza infections. Factors like antigenic selection, antiviral treatment, tissue specificity, spatial structure, and multiplicity of infection may affect how influenza viruses evolve within human hosts. Studies of within-host evolution can contribute to our understanding of the evolutionary and epidemiological factors that shape influenza virus's global evolution.
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