Journal
TRENDS IN IMMUNOLOGY
Volume 39, Issue 6, Pages 503-514Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.02.007
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Funding
- Associazione Italiana per la Ricerca sul Cancero (AIRC) Special Program Molecular Clinical Oncology, 5 per mille [9965]
- AIRC [19867]
- Italian Ministry of Health, Ricerca Finalizzata [RF-2011-02347691]
- Institut Pasteur
- INSERM
- Universite Paris Diderot
- Association pour la Recherche sur le Cancer
- ANR grant 'Myeloten' the Institut National du Cancer (Role of the immune microenvironment during liver carcinogenesis)
- National Health and Medical Research Council of Australia [1078247]
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- National Health and Medical Research Council of Australia [1078247] Funding Source: NHMRC
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The mammalian spleen is a peripheral lymphoid organ that plays a central role in host defense. Consequently, the lack of spleen is often associated with immunodeficiency and increased risk of overwhelming infections. Growing evidence suggests that non-hematopoietic stromal cells are central players in spleen development, organization, and immune functions. In addition to its immunological role, the spleen also provides a site for extramedullary hematopoiesis (EMH) in response to injuries. A deeper understanding of the biology of stromal cells is therefore essential to fully comprehend how these cells modulate the immune system during normal and pathological conditions. Here, we review the specificities of the different mouse spleen stromal cell subsets and complement the murine studies with human data when available.
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