Journal
TRENDS IN IMMUNOLOGY
Volume 39, Issue 5, Pages 419-433Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.01.006
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Funding
- Canadian Institutes of Health Research [154316, 148567, MOP-14181, CPG-127775]
- Natural Sciences and Engineering Research Council of Canada [319834]
- Canadian Foundation for Innovation
- Ontario Government
- McMaster University
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Despite some major progress made in developing tuberculosis (TB) vaccine strategies, with a dozen novel vaccines currently in the clinical pipeline, the world is still missing an effective TB vaccine. This questions whether any major breakthroughs can be achieved without making a drastic departure from the current strategy, which creates a state of 'near-natural immunity', imitating the natural immunity developed after Mycobacterium tuberculosis (Mtb) infection. Here, we argue instead that mounting evidence suggests an effective strategy ought to induce a state of all-around 'un-natural' immunity comprising trained innate immunity (TII), tissue-resident memory T cells (TRM), and anti-Mtb surface antibodies in the lung. Thus, here we summarize the latest information, thinking, and development in the field of TB and vaccines.
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