Journal
TRENDS IN IMMUNOLOGY
Volume 39, Issue 6, Pages 473-488Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.02.009
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Funding
- ARC [DP170102321]
- National Health and Medical Research Council of Australia (NHMRC) [1125316]
- NHMRC [1107914, 1117017]
- University of Queensland Postdoctoral Research Fellowship
- ARC Centre of Excellence in Advanced Molecular Imaging [CE140100011]
- Biomedical Research Council A*STAR Young Investigator Grant [1518251030]
- SIgN A*STAR [A*STAR JCO-CDA15302FG151]
- Singapore-India joint grant [1518224018]
- National Health and Medical Research Council of Australia [1125316, 1107914] Funding Source: NHMRC
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Regulated cellular metabolism has emerged as a fundamental process controlling macrophage functions, but there is still much to uncover about the precise signaling mechanisms involved. Lysine acetylation regulates the activity, stability, and/or localization of metabolic enzymes, as well as inflammatory responses, in macrophages. Two protein families, the classical zinc-dependent histone deacetylases (HDACs) and the NAD-dependent HDACs (sirtuins, SIRTs), mediate lysine deacetylation. We describe here mechanisms by which classical HDACs and SIRTs directly regulate specific glycolytic enzymes, as well as evidence that links these protein deacetylases to the regulation of glycolysis-related genes. In these contexts, we discuss HDACs and SIRTs as key control points for regulating immunometabolism and inflammatory outputs from macrophages.
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