Journal
TRENDS IN GENETICS
Volume 34, Issue 4, Pages 279-290Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2017.12.012
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Funding
- NHMRC [1127745]
- innovation fellowship from veski
- National Health and Medical Research Council of Australia [1127745] Funding Source: NHMRC
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Splicing and nuclear export of mRNA are critical steps in the gene expression pathway. While RNA processing factors can perform general, essential functions for intron removal and bulk export of mRNA, emerging evidence highlights that the core RNA splicing and export machineries also display regulatory potential. Here, we discuss recent insights into how this regulatory potential can selectively alter gene expression and regulate important biological processes. We also highlight the participation of RNA processing pathways in the cellular response to DNA damage at multiple levels. These findings have important implications for the contribution of selective mRNA processing and export to the development of human cancers and neurodegenerative disorders.
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