Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 29, Issue 5, Pages 349-359Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2018.03.002
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Funding
- National Institutes of Health, Institute of General Medical Sciences [P01GM085354]
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Human stem cell-based models of thermogenic adipocytes provide an opportunity for the establishment of new therapeutics, modeling of disease mechanisms, and understanding of development. Pluripotent stem cells, adipose-derived stem cells/preadipocytes, and programming-reprogramming-based approaches have been used to develop cell-based platforms for drug screening and transplantable therapeutics in the metabolic disease arena. Here we provide a detailed overview of these approaches, the latest advances in this field, and the opportunities and shortcomings they present. Moreover, we comment on how stem-cell-based platforms can be best utilized in the future for the treatment and understanding of metabolic diseases, including type 2 diabetes and associated medical issues such as obesity.
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