Journal
TRENDS IN CELL BIOLOGY
Volume 28, Issue 4, Pages 258-273Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.01.002
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Funding
- Italian Ministry of Education, University and Research
- Italian Ministry of Health
- Telethon [GGP15219/B]
- Italian Association for Cancer Research (AIRC) [IG-18624, IG-19803]
- University of Ferrara
- Fondazione Cariplo grant
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Calcium (Ca2+) is considered one of the most-important biological cations, because it is implicated in cell physiopathology and cell fate through a finely tuned signaling system. In support of this notion, Ca2+ is the primary driver of cell proliferation and cell growth; however, it is also intimately linked to cell death. Functional abnormalities or mutations in proteins that mediate Ca2+ homeostasis usually lead to a plethora of diseases and pathogenic states, including cancer, heart failure, diabetes, and neurodegenerative disease. In this review, we examine recent discoveries in the highly localized nature of Ca2+-dependent signal transduction and its roles in cell fate, inflammasome activation, and synaptic transmission.
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