Journal
TRENDS IN CELL BIOLOGY
Volume 28, Issue 6, Pages 475-493Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.02.003
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Funding
- Australian Federal Government postgraduate award
- Australian National Health and Medical Research Council [1113577, 1077750, 1063008, 361646]
- Victorian State Government Operational Infrastructure support grant
- Monash University Faculty of Medicine, Nursing, and Health Sciences
- DHB Foundation
- National Health and Medical Research Council of Australia [1077750, 1063008] Funding Source: NHMRC
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The mitochondrial caspase cascade was originally thought to be required for apoptotic death driven by Bak/Bax-mediated intrinsic apoptosis. It has also been ascribed several 'non-apoptotic' functions, including differentiation, proliferation, and cellular reprogramming. Recent work has demonstrated that, during apoptosis, the caspase cascade suppresses damage-associated molecular pattern (DAMP)-initiated production of cytokines such as type I interferon by the dying cell. The caspase cascade is not required for death to occur; instead, it shapes the immunogenic properties of the apoptotic cell. This raises questions about the role of apoptotic caspases in regulating DAMP signaling more generally, puts a new perspective on their non-apoptotic functions, and suggests that pharmacological caspase inhibitors might find new applications as antiviral or anticancer agents.
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