Journal
TRENDS IN CELL BIOLOGY
Volume 28, Issue 6, Pages 420-435Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.02.004
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Funding
- Hungarian Academy of Sciences
- KU Leuven
- Fund for Scientific Research Flanders (FWO-Vlaanderen)
- 'Agency for Innovation by Science and Technology in Flanders' (IWT-Vlaanderen)
- ALS Liga (Belgium)
- EMBO
- Odysseus grant from FWO-Vlaanderen [G.0029.12]
- European Research Council under the European Union's Horizon Framework Programme ERC [647458]
- NIGMS [R01GM118530]
- [GINOP-2.3.2-15-2016-00044]
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Cellular compartments and organelles organize biological matter. Most well-known organelles are separated by a membrane boundary from their surrounding milieu. There are also many so-called membraneless organelles and recent studies suggest that these organelles, which are supramolecular assemblies of proteins and RNA molecules, form via protein phase separation. Recent discoveries have shed light on the molecular properties, formation, regulation, and function of membraneless organelles. A combination of techniques from cell biology, biophysics, physical chemistry, structural biology, and bioinformatics are starting to help establish the molecular principles of an emerging field, thus paving the way for exciting discoveries, including novel therapeutic approaches for the treatment of age-related disorders.
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