Journal
TRENDS IN CELL BIOLOGY
Volume 28, Issue 9, Pages 709-722Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.05.002
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Funding
- EMBO Long-Term Fellowship [ALTF 594-2014]
- EMBO Advanced Fellowship [ALTF 523-2017]
- Wellcome Trust [206439/Z/17/Z]
- Medical Research Council [MR/PO18823/1]
- National Institute for Health Research [IS-BRC-1215-20006]
- Cancer Research UK [C219/A23522]
- MRC [G1100073, MR/P018823/1] Funding Source: UKRI
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Skin architecture and function depend on diverse populations of epidermal cells and dermal fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in skin development, homeostasis and repair. While several stem cell populations have been identified in the epidermis with distinct locations and functions, it is now recognised that there is additional heterogeneity within the mesenchymal cells of the dermis. Here, we discuss recent insights into how these distinct cell populations are maintained and coordinated during development, homeostasis, and wound healing. We highlight the importance of the local environment, or niche, in cellular plasticity. We also discuss new mechanisms that have been identified as influencing wound repair and cancer progression.
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