Journal
TRENDS IN CELL BIOLOGY
Volume 28, Issue 10, Pages 764-775Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.05.004
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Funding
- NIH K22 award [K22 CA175228-01A1]
- NIH DP2 award [DP2 CA206653]
- Donald E. and Delia B. Baxter Foundation
- Stop Cancer Foundation
- Wright Foundation
- Pew Charitable Trusts
- Alexander & Margaret Stewart Trust (Pew-Stewart Scholar for Cancer Research)
- National Cancer Institute of the National Institutes of Health [F31CA213970]
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Whole-genome sequencing has made a significant impact on cancer research, but traditional bulk methods fail to detect information from rare cells. Recently developed single-cell sequencing methods have provided new insights and unprecedented details about cancer progression and diversity. These advancements also enable the investigation of rare cells, such as circulating tumor cells (CTCs) derived from cancer patients. In this review, we outline various single-cell sequencing techniques that can elucidate the molecular properties of CTCs. In addition, we explain the drawbacks that need to be overcome for each method.
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