Journal
TRENDS IN CELL BIOLOGY
Volume 28, Issue 5, Pages 356-367Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.01.008
Keywords
-
Categories
Funding
- Spanish Ministry of Economy and Competitiveness [BFU2015-65074-P, BFU2016-79916-P]
- European Commission [H2020-FETPROACT-01-2016-731957]
- Generalitat de Catalunya [2014-SGR-927]
- European Research Council [CoG-616480]
- Obra Social La Caixa
- Juan de la Cierva Fellowship (Spanish Ministry of Economy and Competitiveness) [IJCI-2014-19156]
Ask authors/readers for more resources
The linkage of cells to their microenvironment is mediated by a series of bonds that dynamically engage and disengage, in what has been conceptualized as the molecular clutch model. Whereas this model has long been employed to describe actin cytoskeleton and cell migration dynamics, it has recently been proposed to also explain mechanotransduction (i.e., the process by which cells convert mechanical signals from their environment into biochemical signals). Here we review the current understanding on how cell dynamics and mechanotransduction are driven by molecular clutch dynamics and its master regulator, the force loading rate. Throughout this Review, we place a specific emphasis on the quantitative prediction of cell response enabled by combined experimental and theoretical approaches.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available