Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 28, Issue 2, Pages 81-90Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2017.08.002
Keywords
Noncoding RNA; Small Cajal body-associated RNA; Spliceosomal RNA; Small nucleolar RNA; Alternative splicing
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Funding
- American Heart Association, United States [16GRNT30950010]
- National Institutes of Health COBRE, United States [P20GM104936]
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Small nucleolar RNAs (snoRNAs) are a group of noncoding RNAs that perform various biological functions, including biochemical modifications of other RNAs, precursors of miRNA, splicing, and telomerase activity. The small Cajal body-associated RNAs (scaRNAs) are a subset of the snoRNA family and collect in the Cajal body where they perform their canonical function to biochemically modify spliceosomal RNAs prior to maturation. Failure of sno/scaRNAs have been implicated in pathology such as congenital heart anomalies, neuromuscular disorders, and various malignancies. Thus, understanding of sno/scaRNAs demonstrates the clinical value.
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