Journal
TRENDS IN BIOTECHNOLOGY
Volume 36, Issue 12, Pages 1275-1286Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2018.06.008
Keywords
-
Categories
Funding
- German cancer network (DKTK)
- DFG
- SGC
Ask authors/readers for more resources
Chemical probes represent versatile tools to validate disease-modifying targets. However, evaluating the selectivity of chemical probes in complex cellular systems is a major challenge that needs to be addressed to better understand the mode of action of small molecules and the interpretation of their pharmacological effects. Chemoproteomics has emerged as a key technology to characterize the mode of action of pharmacological modulators such as chemical probes and drugs, and these studies have unraveled the cellular targets of many bioactive compounds. Here we review the role of chemical probes for the validation of new therapeutic targets and their characterization by proteome wide affinity-and activity-based chemical proteomics and recently developed label-free technologies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available