Journal
TRENDS IN BIOTECHNOLOGY
Volume 36, Issue 1, Pages 60-72Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2017.10.003
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- Swiss National Science Foundation as part of the National Centre of Competence in Research (NCCR) in Molecular Systems Engineering
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Residing at the interface of chemistry and biotechnology, artificial metalloenzymes (ArMs) offer an attractive technology to combine the versatile reaction repertoire of transition metal catalysts with the exquisite catalytic features of enzymes. While earlier efforts in this field predominantly comprised studies in well-defined test-tube environments, a trend towards exploiting ArMs in more complex environments has recently emerged. Integration of these artificial bio-catalysts in enzymatic cascades and using them in whole-cell biotransformations and in vivo opens up entirely novel prospects for both preparative chemistry and synthetic biology. We highlight selected recent developments with a particular focus on challenges and opportunities in the in vivo application of ArMs.
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