Journal
TRENDS IN BIOTECHNOLOGY
Volume 36, Issue 9, Pages 952-965Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2018.04.002
Keywords
-
Categories
Funding
- European Research Council [309384]
- Netherlands Organisation for Scientific Research (NWO Gravitation Programme Cancer Genomics Netherlands)
- Dutch Cancer Society (KWF)
- European Research Council (ERC) [309384] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
DNA methylation is an epigenetic modification that plays an important role in gene expression regulation, development, and disease. Recent technological innovations have spurred the development of methods that enable us to study the occurrence and biology of this mark at the single-cell level. Apart from answering fundamental biological questions about heterogeneous systems or rare cell types, low-input methods also bring clinical applications within reach. Ultimately, integrating these data with other single-cell data sets will allow deciphering multiple layers of gene expression regulation within each individual cell. Here, we review the approaches that have been developed to facilitate single-cell DNA methylation profiling, their biological applications, and how these will further our understanding of the biology of DNA methylation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available