Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 43, Issue 5, Pages 358-368Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2018.01.005
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Funding
- National Institutes of Health [HL020948, GM112409, GM116106]
- Welch Foundation [I-1832]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL020948] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM112409, R01GM116106] Funding Source: NIH RePORTER
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Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, proteolytic activation, and transcriptional activity. In this review, we summarize the recent findings that contribute to the current understanding of the regulation of SREBPs and their physiologic roles in maintenance of lipid homeostasis, insulin signaling, innate immunity, and cancer development.
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