Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 43, Issue 2, Pages 95-107Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2017.11.010
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Funding
- Natural Science Foundation of China [31770813, 81773771]
- Ministry of Economy, Research and Digitalization [Science and Research in Saxony-Anhalt by budget funds of the European Structural and Investment Fund (ESIF)] [ZS/2016/04/78155]
- US National Institutes of Health [GM105802, GM121834]
- Foreign 1000 Talent Program of the Government of the People's Republic of China
- 100 Talent Program of the Province of Fujian, China
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Specificity of the ubiquitin proteasome system is controlled by ubiquitin E3 ligases, including their major representatives, the multisubunit cullin-RING ubiquitin (Ub) ligases (CRLs). More than 200 different CRLs are divided into seven families according to their cullin scaffolding proteins (CUL1-7) around which they are assembled. Research over two decades has revealed that different CRL families are specialized to fulfill specific cellular functions. Whereas many CUL1-based CRLs (CRL1s) ubiquitylate cell cycle regulators, CRL4 complexes often associate with chromatin to control DNA metabolism. Based on studies about differentiation programs of mesenchymal stem cells (MSCs), including myogenesis, neurogenesis, chondrogenesis, osteogenesis and adipogenesis, we propose here that CRL3 complexes evolved to fulfill a pivotal role in mammalian cell differentiation.
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