Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 20, Issue 3, Pages -Publisher
WILEY
DOI: 10.1111/tid.12878
Keywords
cystic fibrosis; isavuconazole; lung transplant; mucormycosis; pharmacokinetics
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Previous studies of patients with cystic fibrosis (CF) treated with azole antifungals have shown altered pharmacokinetics relative to healthy patients. Data regarding the pharmacokinetic profile of isavuconazole in patients with CF undergoing lung transplantation are currently not available. Serum trough concentrations assessed in a single CF patient following transplant revealed significantly lower values relative to available literature. Larger studies are required to validate CF population pharmacokinetics of isavuconazole.
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