Journal
TRANSLATIONAL RESEARCH
Volume 198, Issue -, Pages 17-28Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trsl.2018.03.003
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Funding
- NIH [UH3HL123502, 2P50AR060780, P01HL114453]
- United States Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development
- United States Department of Veterans Affairs
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The present review aims to summarize available knowledge on the role of the ubiquitin-proteasome system (UPS) in the pathogenesis of scleroderma and scleroderma-related disease mechanisms. This will provide the reader with a more mechanistic understanding of disease pathogenesis and help to identify putative novel targets within the UPS for potential therapeutic intervention. Because of the heterogenous manifestations of scleroderma, we will primarily focus on conserved mechanisms that are involved in the development of lung scleroderma phenotypes.
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