Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 98, Issue -, Pages 174-189Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2017.11.010
Keywords
Biomolecules; Carbon nanomaterials (CNs); Voltammetry; Nanosensors; Sensitivity
Categories
Funding
- Chinese Academy of Sciences [2015PM002]
- National Natural Science Foundation of China [21577139]
- Special Fund for Agro-scientific Research in the Public Interest [201503108]
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Biomolecules are integral constituents of living beings which regulate numerous biochemical functions of the body. Analysis of various small molecules (metabolites, neurotransmitters, amino acids, vitamins) and macromolecules (nucleic acids, proteins) is of prime importance in modern time due to increasing disbalance in natural metabolism of human body. Irregularities and alteration in concentration of biomolecules lead to different kinds of genetic, metabolic and cancerous diseases which have created a great requirement of highly sensitive, accurate and stable detection systems for their quick and specific screening. In this review, redox interactions of biomolecules at carbon based electrode interfaces have been discussed using voltammetry. It is divided into subsections, starting with an introduction into the field and a description of its current state. This is followed by a large section describing carbon nano materials (CNs) based voltammetric sensors for different small biomolecules and macromolecules. The next section of the review gives conclusion, challenges and future perspectives in sensing biomolecules at CNs based electrodes. Advanced approaches for fabrication of portable integrated electrochemical devices for various point of care diagnostic applications have also been included at the end. (C) 2017 Elsevier B.V. All rights reserved.
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